Compartmentalization of the inflammatory response during bacterial sepsis and severe COVID-19

Compartmentalization of the inflammatory response during bacterial sepsis and severe COVID-19

Blog Article

Acute infections cause local and systemic disorders which can lead in the most severe forms to multi-organ failure and eventually to death.The host response to infection encompasses a large spectrum of reactions with a concomitant activation of the so-called inflammatory response aimed at fighting the infectious agent and removing damaged tissues or cells, and the anti-inflammatory response aimed at controlling inflammation and EA Furniture initiating the healing process.Fine-tuning at the local and systemic levels is key to preventing local and remote injury due to immune system activation.

Thus, during bacterial sepsis and Coronavirus disease 2019 (COVID-19), concomitant systemic and compartmentalized pro-inflammatory and compensatory anti-inflammatory responses are occurring.Immune cells (e.g.

, macrophages, neutrophils, natural killer cells, and T-lymphocytes), as DANDRUFF/DRY SCALP CONDITIONER well as endothelial cells, differ from one compartment to another and contribute to specific organ responses to sterile and microbial insult.Furthermore, tissue-specific microbiota influences the local and systemic response.A better understanding of the tissue-specific immune status, the organ immunity crosstalk, and the role of specific mediators during sepsis and COVID-19 can foster the development of more accurate biomarkers for better diagnosis and prognosis and help to define appropriate host-targeted treatments and vaccines in the context of precision medicine.